HbA1c in Polycystic Ovary Syndrome as the Cardiac Risk Assessment

Adhe Rojekar, Arati; Vijay Rojekar, Mohit; B. Ghanghurde, Swati; Lalla, Poonam

doi:10.18502/ijdo.v14i1.8732

Volume 14, Issue 1 (2-2022) IJDO 2022, 14(1): 9-13 | Back to browse issues page

‎ 10.18502/ijdo.v14i1.8732

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Adhe Rojekar A, Vijay Rojekar M, B. Ghanghurde S, Lalla P. HbA1c in Polycystic Ovary Syndrome as the Cardiac Risk Assessment. IJDO 2022; 14 (1) :9-13
URL: http://ijdo.ssu.ac.ir/article-1-681-en.html

HbA1c in Polycystic Ovary Syndrome as the Cardiac Risk Assessment

Arati Adhe Rojekar

, Mohit Vijay Rojekar

, Swati B. Ghanghurde

, Poonam Lalla ^*

Family Physician, Chembur, Mumbai, India.

Abstract: (1744 Views)

Objective: Polycystic ovary syndrome (PCOS) is an endocrine disorder associated with hyperandrogenism marked with hirsutism and ovarian dysfunction. These conditions may lead to the risk of insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. These conditions are related to PCOS complications hence our aim was to study and investigate the relationship between high-sensitivity C - reactive protein (hs-CPR) level and glycosylated hemoglobin (HbA1c) level in PCOS patients.
Materials and Methods: Female patients visiting the obstetrics and gynecology outpatient department (OPD), aged between 19 and 45 years with a body mass index (BMI) of 25 to 29 kg/m². The individuals fulfilling the National Institute of Health (NIH) criteria for PCOS; including amenorrhea or oligomenorrhea and had been clinically diagnosed with hyperandrogenism were served as subjects.
Results: Two hundred and ten individuals with HbA1c of 5.4% have a higher risk of cardiovascular disorders. The study showed the association between increased cardiac risk as measured by hs-CRP and patients with normal HbA1c values with a sensitivity of 77.2% and specificity of 75.99%. The HbA1c cutoff value can be used in the PCOS patients to assess the cardiac risk due to association of HbA1c cut off value with false positivity rate of 15.24%.
Conclusion: In PCOS patients with chronic low-grade inflammation, IR, and the degree of inflammation associated with HbA1c value was observed.

Keywords: HbA1c, Polycystic ovary syndrome, hs-CRP, Cardiovascular disorder

Full-Text [PDF 475 kb] (451 Downloads)

Type of Study: Research | Subject: Special
Received: 2021/09/25 | Accepted: 2022/01/1 | Published: 2022/02/26

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